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目的观察光动力疗法治疗口腔黏膜癌前病变及口腔癌的临床疗效。方法临床及病理确诊的口腔黏膜扁平苔藓和鳞癌患者各1例,静脉注射光敏剂PSD-007 5 mg/kg后6 h,应用波长630 nm的半导体激光以点状光纤照射,激光功率密度150 mW/cm2,每个光斑照射10～30 min,能量密度90～270 J/cm2。观察患者术中和术后的不良反应。术后4～5周进行近期临床疗效评价。结果 2例患者累计治疗18处病灶,其中15处病灶经1次治疗,2处病灶经2次治疗,1处病灶经3次治疗后痊愈,未见瘢痕形成。2例患者病灶愈合后均无口腔功能及感觉变化。结论光动力疗法具有靶向性好、选择性高、安全可靠、创伤小、可重复应用和对口腔功能无明显损害等优点,是一种安全、值得推广的治疗口腔黏膜癌前病变和口腔癌的高效疗法。
Objective To observe the clinical efficacy of photodynamic therapy in the treatment of oral mucosal precancerous lesions and oral cancer. Methods One patient with oral mucosa lichen planus and squamous cell carcinoma was diagnosed clinically and pathologically. Six hours after intravenous instillation of PSD-007 5 mg / kg, a semiconductor laser with a wavelength of 630 nm was used to irradiate the fiber with a point power of 150 mW / cm2, each light spot irradiation 10 ~ 30 min, energy density 90 ~ 270 J / cm2. Observe the patients intraoperative and postoperative adverse reactions. After 4 to 5 weeks for clinical evaluation of clinical efficacy. Results There were 18 lesions in 2 patients, of which 15 lesions were treated by one treatment, two lesions were treated by two treatments and one was cured by three treatments without any scar formation. Two patients had no oral function and sensory changes after the lesion healed. Conclusion Photodynamic therapy has the advantages of good targeting, high selectivity, safety and reliability, less trauma, repeatable application and no obvious damage to oral function. It is a safe and worthy promotion for the treatment of oral mucosal precancerous lesions and oral cancer Efficient therapy.