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目的通过分析胚胎冷冻保存时间、不同冻融胚胎移植周期与临床妊娠结局的相关性,探讨胚胎玻璃化冷冻在女性生育力保存中的意义。方法回顾性分析2014年1月-2015年9月在泰安市中心医院行冻融胚胎移植的600例患者,按照冷冻保存时间分为A组(1~12个月)、B组(13~18个月)、C组(19~24个月)、D组(>24个月);根据冻融胚胎移植周期数分为第1个移植周期组、第2个移植周期组、第3个移植周期组、≥第4个移植周期组。分别研究胚胎冷冻保存时间、不同移植周期与临床妊娠结局的关系。结果 A、B、C、D组临床妊娠率分别为56.24%、56.04%、44.44%和50.00%,各组比较差异无统计学意义(χ2=1.220,P>0.05)。第1个移植周期组、第2个移植周期组、第3个移植周期组、≥第4个移植周期组临床妊娠率分别为55.29%、56.39%、47.88%和47.05%,各组比较差异无统计学意义(χ2=1.967,P>0.05)。结论长期低温冷冻保存不会降低胚胎发育潜能,是保存女性生育力安全有效的方法。
Objective To investigate the significance of embryo vitrification in the conservation of female fertility by analyzing the relationship between the cryopreservation time of embryos and the cycles of different frozen-thawed embryos and clinical pregnancy outcomes. Methods A retrospective analysis of 600 patients with frozen-thawed embryo transfer from January 2014 to September 2015 in Tai’an Central Hospital was performed and divided into group A (1 to 12 months), group B (13 to 18 Months), group C (19-24 months) and group D (> 24 months). According to the number of cycles of frozen-thawed embryo transfer, the first transplant group, the second transplant group and the third transplant Cycle group, ≥ fourth transplant cycle group. The relationship between embryo cryopreservation time, different graft cycles and clinical pregnancy outcome were studied. Results The clinical pregnancy rates in groups A, B, C and D were 56.24%, 56.04%, 44.44% and 50.00%, respectively. There was no significant difference in each group (χ2 = 1.220, P> 0.05). The clinical pregnancy rates in the first transplant group, the second transplant group, the third transplant group, and the fourth transplant group were 55.29%, 56.39%, 47.88% and 47.05% respectively, with no difference between the groups Statistical significance (χ2 = 1.967, P> 0.05). Conclusion Long-term cryopreservation does not reduce the embryonic development potential and is a safe and effective method to preserve female fertility.