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心肌缺血时的心肌收缩力降低以及心肌细胞膜透过钙离子的性能降低,和细胞内磷酸肌酸含量减少密切相关。实验研究证明,外源性磷酸肌酸能促进心肌缺血后收缩功能的恢复,防止发生心肌缺氧性挛缩,改善缺血区微循环,使坏死区缩小,并有抗心律失常效应, 观察大面积心肌梗塞(心梗)97例。均为男性,年龄25～70岁。71例(第1组)接受传统疗法:硝酸甘油,钙阻滞剂,抗凝,抗心律失常,强心,利尿等。26例(第2组)除传统疗法外,使用磷酸肌酸:心梗后6 h以内静脉注射2 g,然后把8 g溶解在200 ml5％葡萄糖液内静脉滴注2 h,心梗2～6天,
Myocardial ischemia during myocardial contractility and myocardial cell membrane through the performance of calcium decreased, and intracellular phosphocreatine content is closely related. Experimental studies have shown that exogenous creatine phosphate can promote the recovery of myocardial ischemic contractile function, to prevent the occurrence of myocardial hypoxic contracture, improve microcirculation of the ischemic area, the necrotic area reduced, and anti-arrhythmic effect, the observation of large Area myocardial infarction (myocardial infarction) in 97 cases. All men, aged 25 to 70 years old. Totally 71 patients (group 1) underwent conventional therapy: nitroglycerin, calcium blockers, anticoagulation, antiarrhythmic, cardiotonic, diuretic, and the like. 26 cases (group 2) except for traditional therapy, the use of phosphocreatine: within 6 h after myocardial infarction intravenous injection of 2 g, and then 8 g dissolved in 200 ml of 5% glucose solution intravenously for 2 h, myocardial infarction 2 ~ 6 days,