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目的：观察nm23－H1基因表达与涎腺癌发生和转移的关系。方法：采用免疫组织化学法。结果：nm23－H1基因在涎腺癌中表达阳性率为88．33％，癌旁涎腺组织为37.50％；nm23－H1表达的阳性率与涎腺癌发生的部位、肿瘤大小及临床分期无关，而nm23－H1高表达与颈淋巴结转移呈负相关。结论：nm23－H1基因与涎腺癌发生有关；nm23－H1高表达对涎腺癌颈淋巴结转移具有抑制作用．
Objective: To observe the relationship between nm23-H1 gene expression and the occurrence and metastasis of salivary gland carcinoma. Methods: Immunohistochemical method was used. Results: The positive rate of nm23-H1 gene in salivary gland carcinoma was 88.33%, while the paracancer salivary gland tissue was 37.50%. The positive rate of nm23-H1 expression was not related to the location of salivary gland carcinoma, tumor size and clinical stage , While the high expression of nm23-H1 was negatively correlated with cervical lymph node metastasis. Conclusion: The nm23-H1 gene is associated with the development of salivary gland carcinoma. The high expression of nm23-H1 can inhibit the metastasis of cervical lymph node in salivary gland carcinoma.