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目的观察脂化前列腺素E1和盐酸丁咯地尔对糖尿病足的临床疗效。方法糖尿病足患者84例随机分为A、B两组,在控制血糖、抗感染、活血化淤、清创等治疗基础上,A组42例,予以脂化前列腺素E1(PG E1,北京泰德医药股份有限公司产品,商品名:凯时)10μg加入生理盐水100 ml中静脉滴注,1次/d,共4周;B组42例,予以盐酸丁咯地尔150 mg加入生理盐水100 ml中静脉滴注,1次/d,共4周。观察两组治疗方案的有效率和毒副反应情况。结果A组有效率为95.2%,B组有效率为88.1%,两组治疗后无显著差异(P>0.05)。结论脂化前列腺素E1和盐酸丁咯地尔对糖尿病足均有治疗作用。
Objective To observe the clinical efficacy of lipidated prostaglandin E1 and buflomedil hydrochloride on diabetic foot. Methods Eighty-four patients with diabetic foot were randomly divided into A and B groups. On the basis of controlling blood sugar, anti-infective, promoting blood circulation and debridement, 42 cases in group A were treated with prostaglandin E1 (PG E1, Germany Pharmaceutical Co., Ltd. product, trade name: Kay hours) 10μg added 100 ml of normal saline intravenous infusion, 1 times / d, a total of 4 weeks; B group 42 cases, to buflomedil hydrochloride 150 mg saline 100 ml intravenous infusion, 1 / d, a total of 4 weeks. Observe the two groups of treatment options efficiency and toxicity. Results The effective rate was 95.2% in group A and 88.1% in group B, with no significant difference between the two groups (P> 0.05). Conclusion Lipid prostaglandin E1 and buflomedil hydrochloride have therapeutic effects on diabetic foot.