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目的探讨糖耐量受损患者血清胱抑素C(S-cysC)检测对早期肾损害的意义。方法根据糖耐量试验(OGTT)结果选择研究对象:糖调节正常组(NGT)63例;空腹血糖受损组(IFG)41例;糖耐量受损组(IGT)49例。分别检测其S-cysC和尿微量白蛋白(u-mAlB)。结果IFG组与NGT组比较:S-cysC(0.96±0.15)vs(0.91±0.14)mg/L(P>0.05);u-mAlB(14.7±2.9)vs(13.5±3.5)mg/24h(P>0.05)。IGT组与NGT组比较:S-cysC(1.41±0.56)vs(0.91±0.14)mg/L(P<0.01);u-mAlB(15.4±4.3)vs(13.5±3.5)mg/24h(P<0.05)。IGT组S-cysC与u-mAlB异常率比较:30.6%vs12.2%(P<0.01)。结论IGT患者可引起肾损害,CysC是早期肾损害的敏感指标,对IGT患者肾损害诊断有重要参考价值。
Objective To investigate the significance of serum cystatin C (S-cysC) detection in patients with impaired glucose tolerance. Methods According to the result of glucose tolerance test (OGTT), 63 subjects were selected as normal control group (NGT), 41 as impaired fasting glucose group (IFG) and 49 as impaired glucose tolerance group (IGT). The S-cysC and urinary microalbumin (u-mAlB) were detected respectively. Results Compared with NGT group, there were no significant differences in the levels of s-cysC (0.96 ± 0.15) vs (0.91 ± 0.14) mg / L (P> 0.05) > 0.05). The levels of S-cysC (1.41 ± 0.56) vs (0.91 ± 0.14) mg / L (P <0.01) in IGT group and NGT group (15.4 ± 4.3) vs (13.5 ± 3.5) mg / 0.05). The abnormal rates of S-cysC and u-mAlB in IGT group were 30.6% vs12.2% (P <0.01). Conclusion IGT patients can cause renal damage, CysC is a sensitive indicator of early renal damage, IGT patients with renal damage diagnosis has important reference value.