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目的：研究地塞米松对大鼠脑免疫反应的影响，探讨其对某些类型癫痫的治疗机理。方法：美解眠致痫及致痫前后分别给予地塞米松的大鼠用免疫细胞化学法观察ＩｇＧ免疫反应阳性（ＩｇＧＩＲ）细胞在大鼠脑组织内分布。结果：致痫前给予地塞米松大鼠脑皮层和海马ＩｇＧＩＲ细胞数比单纯致痫组减少（Ｐ＜００１，Ｐ＜００５）；致痫后给予地塞米松组大鼠，只有海马ＩｇＧＩＲ细胞数比单纯致痫组增多（Ｐ＜００１）。结论：地塞米松对脑免疫反应的调节在某些类型癫痫的治疗中可能有一定意义。
Objective: To study the effect of dexamethasone on brain immune response in rats and explore its therapeutic mechanism for some types of epilepsy. METHODS: Rats immunized with dexamethasone before and after epileptogenic and pre-eclampsia were respectively immunostained to observe the distribution of IgG immunoreactive (IgG-IR) cells in rat brain. Results: The number of IgG-IR cells in dexamethasone-induced cortex and hippocampus in preeclampsia rats was lower than that in epilepsy rats (P <001, P <005) , Only the number of hippocampal IgG IR cells increased compared with epilepsy group (P <0 01). Conclusion: The regulation of dexamethasone on the brain immune response may be of some significance in the treatment of some types of epilepsy.