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目的:探讨卵巢型子宫内膜异位症患者中癌抗原125(CA125)的表达特点及相关影响因素。方法:采用回顾性的研究方法,收集卵巢型子宫内膜异位症的病案150例,采用SPSS11.5软件进行统计分析。结果:150例患者中,术前测CA125者133例,64例在正常范围(48.1%),69例超过参考值(51.9%)。58例(38%)以疼痛为主诉就诊而发现卵巢囊肿和27例(18%)合并有子宫腺肌症患者,CA125表达均无统计学差异(P>0.05)。卵巢囊肿发生于左侧共111例,右侧96例。囊肿发生侧别、生育次数及流产次数对CA125表达影响差异无统计学意义(P>0.05)。结论:引起CA125变化非单一因素,CA125对于卵巢型子宫内膜异位症的敏感性为51.9%,且CA125表达与卵巢囊肿发生侧别及生育、流产次数无明显相关性。
Objective: To investigate the expression of cancer antigen 125 (CA125) in ovarian endometriosis and related factors. Methods: A retrospective study was conducted to collect 150 cases of ovarian endometriosis and analyzed by SPSS11.5 software. Results: Of the 150 patients, 133 were preoperatively diagnosed as having CA125, 64 in the normal range (48.1%) and 69 (51.9%) in the 69 patients. There were no significant differences in CA125 expression in 58 cases (38%) who were mainly complained of pain and found ovarian cysts and 27 cases (18%) with adenomyosis. Ovarian cyst occurred in the left 111 cases, the right 96 cases. There was no significant difference in the expression of CA125 between cyst occurrence side, birth frequency and the number of miscarriage (P> 0.05). CONCLUSION: The CA125 changes were not the only cause. The sensitivity of CA125 to ovarian endometriosis was 51.9%. There was no significant correlation between the expression of CA125 and ovarian cysts.