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目的探讨大肠癌患者血清中基质金属蛋白酶-9(MMP-9)的表达特点。方法选取经病理切片证实的大肠癌患者60例作为大肠癌组,良性大肠肿瘤组40例,健康对照组30例,空腹抽取静脉血检测MMP-9含量,并探讨其变化特点。结果大肠癌组MMP-9含量高于对照组及大肠良性肿瘤组,差异有统计学意义(P<0.01),而大肠良性肿瘤组与对照组比较,差异无统计学意义(P>0.05)。MMP-9水平在Ducks分期中A期明显低于B、C、D期(P<0.05);淋巴有转移者明显大于淋巴无转移者,差异均有统计学意义(P<0.05);病理分级G1、G2、G3比较,差异无统计学意义(P>0.05)。结论 MMP-9在大肠癌患者血清中有较高的表达,且与大肠癌的分期,转移有较密切的联系。
Objective To investigate the expression of matrix metalloproteinase-9 (MMP-9) in patients with colorectal cancer. Methods Sixty cases of colorectal cancer confirmed by pathology were selected as colorectal cancer group, 40 cases of benign colorectal tumor group and 30 healthy control group. The content of MMP-9 in venous blood was determined by fasting sampling and the change characteristics were discussed. Results The content of MMP-9 in colorectal cancer group was significantly higher than that in control group and benign colorectal tumor group (P <0.01), but there was no significant difference between benign tumor group and control group (P> 0.05). The level of MMP-9 in Ducks stage A was significantly lower than that in stage B, C and D (P <0.05). The levels of MMP-9 in lymph node metastasis were significantly higher than those without lymph node metastasis (P <0.05) G1, G2, G3, the difference was not statistically significant (P> 0.05). Conclusion MMP-9 is highly expressed in the serum of patients with colorectal cancer, and is closely related to the staging and metastasis of colorectal cancer.