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目的探讨HA(高三尖杉酯碱,HHT+阿糖胞苷,Ara-C)、AD(Ara-C+柔红霉素,DNR)、ANVT(Ara-C+米托蒽醌,NVT)等方案治疗初治急性髓细胞白血病(AML)的疗效、影响疗效的因素及完全缓解(CR)后序贯化疗的效果。方法选用HA、AD、ANVT等方案诱导缓解治疗初治AML(M3即急性早幼粒细胞白血病用全反式维甲酸,ATRA),CR后选用3～4种有效方案序贯化疗。结果HA、AD、ANVT等方案治疗初治AMLCR率高,但对难治性白血病疗效不理想。结论HA、AD、ANVT等方案治疗初治AML,疗效确切、毒副作用轻,价格相对低廉,是基层医院值得推崇的化疗方案;AML获CR后选用3～4种有效方案序贯化疗,可争取长期无病生存。
Objective To investigate the effects of HA (homoharringtonine, HHT + cytarabine, Ara-C), AD (Ara-C + daunorubicin, DNR) and ANVT (Ara-C + mitoxantrone, NVT) Therapeutic efficacy of acute myeloid leukemia (AML), factors influencing efficacy and sequential chemotherapy after complete remission (CR). Methods HA, AD, ANVT and other regimens were used to induce the initial treatment of AML (ATRA for acute promyelocytic leukemia). Three to four effective regimens of sequential chemotherapy were selected after CR. Results HA, AD, ANVT and other programs initial treatment of AMLCR rate, but not effective refractory leukemia. Conclusions HA, AD, ANVT and other regimens for the treatment of initially untreated AML, curative effect is exact, light side effects, the price is relatively low, is the grass-roots hospital worthy of respected chemotherapy; AML obtained after CR 3 ~ 4 effective sequential chemotherapy, Long-term disease-free survival.