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作者报告了静脉输注大剂量人类 IgG 治疗经肾活检证实的原发性膜性肾病(IMGN)的初步结果。本文9例病人均为 IMGN 的肾病综合征(NS),在接受该疗法前6个月,都需要利尿药和人类白蛋白来控制 NS 病情。作者根据肾功能将病人分成二组。肾功能正常(Ccr∶125.24±16ml/min/1.73M~2)的5例为A组,其中男性3例,女性2例,年龄20～49岁,平均33.2岁,病程17.6±10个月,尿蛋白7.2±1.7g/d。轻度肾功能不全(Ccr∶65.5±8.8ml/min/1.73M~2)4
The authors report preliminary results of intravenous infusion of high-dose human IgG in the treatment of idiopathic membranous nephropathy (IMGN) confirmed by renal biopsy. All 9 patients in this study were nephrotic syndrome (NS) with IMGN. Diuretics and human albumin were required to control NS status 6 months prior to receiving this therapy. The authors divided the patients into two groups based on renal function. Five patients with normal renal function (Ccr: 125.24 ± 16ml / min / 1.73M ~ 2) were in group A, including 3 males and 2 females, aged from 20 to 49 years, with an average of 33.2 years and a duration of 17.6 ± 10 months. Urinary protein 7.2 ± 1.7g / d. Mild renal insufficiency (Ccr: 65.5 ± 8.8ml / min / 1.73M ~ 2) 4