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Based on multi-body dynamics, the simulation models of auto-side structures and occupant’s dynamic responses are set up, using the occupant injury simulation software MADYMO3D. These models include auto-body structure, impact barrier, seat and dummy. Definitions of multi-body and joints and dynamics properties of joints based on FE combination models, of model setup are introduced. Kelvin element of MADYMO is introduced to show the force action between non-adjoining rigid bodies, too. Then all examples of the methods mentioned are given. By the comparison of simulation and real test, the contract curves between simulation and real test for main structures and biology mechanics properties of dummy are obtained. The result shows the accuracy and validity of the models.