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经前期综合征(PMS)的病因学中,曾有人提出因前列腺素(PGs)过多的假设,但至今才进行对照研究,而且用PG抑制剂治疗PMS,出现了与此假设相矛盾的结果。为了确证PGs在PMS病因学中的作用,作者对PGs抑制剂——甲氧萘丙酸钠治疗经前期综合征进行了临床疗效观察。采用的方式为双盲式并与安慰剂相对照。受试者共28人,年龄为20～34岁,月经周期为22～33天,患PMS 2～7年,无任何其它疾病并经检查排除任何精神病疾患。试验中,将病人分为安慰剂组(A组)和药物组(B组)。前三个月经周期中,A组服用安慰
In the etiology of premenstrual syndrome (PMS), there have been hypotheses for the excess of prostaglandins (PGs), but control studies have so far been carried out, and the treatment of PMS with PG inhibitors has led to conflicting findings . To confirm the role of PGs in the etiology of PMS, we investigated the clinical efficacy of PGs inhibitor-naproxen sodium in the treatment of premenstrual syndrome. The approach was double-blind and placebo-controlled. A total of 28 subjects, aged 20 to 34 years, the menstrual cycle is 22 to 33 days, with PMS 2 to 7 years, without any other diseases and checked to rule out any mental illness. In the trial, patients were divided into placebo (group A) and drug group (group B). The first three menstrual cycles, Group A taking comfort