论文部分内容阅读
目的:探讨血浆同型半胱氨酸(Homocysteine,Hcy)、高敏C反应蛋白(Hypersensitive C-reactive protein,hs-CRP)在家族性高胆固醇血症(FH)的纯合子和杂合子患者中的水平及其与临床生化指标的相关性。方法:入选在2013.10~2015.7期间在动脉硬化门诊随访、确诊的家族性高胆固醇患者34人(纯合子14例,杂合子20例)。根据FH纯合子、杂合子、健康体检者分成三组,分别测定其总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(Glu)、Hcy、hs-CRP水平,并比较FH患者血浆LDL-C、非高密度脂蛋白(non-HDL)水平Hcy、hs-CRP水平的相关性。结果:FH组的TC、LDL-C、non-HDL、Hcy水平显著高于正常对照组(P<0.05)。FH根据基因型亚组分析中,青少年纯合子组HDL-C[(0.78±0.21)vs(1.25±0.40)mmol/L]小于杂合子组(P<0.001),而TC[(16.11±2.66)vs(7.30±2.54)mmol/L]、LDL-C[(14.06±2.22)vs(5.25±2.16)mmol/L]、non-HDL[(15.33±2.60)vs(6.05±2.61)mmol/L]、Hcy[(19.3±11.58)vs(11.29±3.42)μmol/L]水平显著高于杂合子组(P<0.05)。Pearson相关性分析显示,FH患者血浆LDL-C、non-HDL水平与Hcy水平呈正相关(P<0.05),而与hs-CRP无相关性。结论:FH患者,特别是青少年的纯合子患者,与对照组相较,具有较高的TC、LDL-C和Hcy水平,并且与血浆LDL-C、non-HDL水平呈正相关。FH患者hs-CRP的水平高于健康人,但差异无统计学意义,与血浆LDL-C、non-HDL水平也无明显相关性。
Objective: To investigate the levels of plasma homocysteine (Hcy) and hs-CRP in patients with homozygous and heterozygous familial hypercholesterolemia (FH) And its correlation with clinical biochemical indexes. Methods: 34 patients with familial hypercholesterolemia (14 homozygous and 20 heterozygous) were enrolled in the outpatient department of arteriosclerosis from 2013.10 to 2015.7. According to the FH homozygotes, heterozygotes, healthy subjects were divided into three groups, respectively, measured total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL- C, Glu, Hcy and hs-CRP in patients with FH, and compared the plasma levels of LDL-C and non-HDL Hcy and hs-CRP in patients with FH. Results: The levels of TC, LDL-C, non-HDL and Hcy in FH group were significantly higher than those in normal control group (P <0.05). FH was less than heterozygous (HDL-C [(0.78 ± 0.21) vs (1.25 ± 0.40) mmol / L] in the homozygous adolescent group and TC [(16.11 ± 2.66) (14.06 ± 2.22 vs 5.25 ± 2.16 mmol / L], non-HDL [(15.33 ± 2.60) vs (6.05 ± 2.61) mmol / L] , Hcy [(19.3 ± 11.58) vs (11.29 ± 3.42) μmol / L] were significantly higher than those in the heterozygote group (P <0.05). Pearson correlation analysis showed that plasma LDL-C and non-HDL levels in FH patients were positively correlated with Hcy (P <0.05), but not with hs-CRP. CONCLUSIONS: FH patients, especially adolescent homozygotes, have higher levels of TC, LDL-C and Hcy than those in the control group, and are positively correlated with plasma LDL-C and non-HDL levels. The level of hs-CRP in patients with FH was higher than that in healthy people, but the difference was not statistically significant, nor was there any significant correlation with plasma LDL-C and non-HDL levels.