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目的探讨患者抗生殖免疫抗体及性激素的变化与子宫内膜异位症(endometriosis,EMS)发病的关系。方法回顾性分析268例EMS患者(其中年龄>35岁组的EMS患者90例;年龄≤35岁组的EMS患者178例)和200例非子宫内膜异位症患者(其中年龄>35岁组的非子宫内膜异位症患者72例,为同龄对照组;年龄≤35岁组的非子宫内膜异位症患者128例,为同龄对照组)的临床资料。用化学发光免疫分析法检测两组患者血清卵泡刺激素(follicle-stimulating homone,FSH)、黄体生成素(homone,LH)、睾酮(testosterone,T)、雌二醇(estradiol,E2)孕酮(progesterone,P)和泌乳素(prolactin,PRL)水平;采用酶联免疫法检测抗卵巢抗体(anti-ovarian antibodies,AO-Ab)、抗心磷脂抗体(anticardiolipin antibody,ACL)、抗子宫内膜抗体(anti-endometrial antibodies,EMAb)水平。结果年龄>35岁组和年龄≤35岁组EMS患者的P、PRL水平均高于同龄对照组,差异有统计学意义;年龄>35岁组的EMS患者LH水平也显著高于同龄对照组,差异也有统计学意义(P<0.05)。其他激素各项指标比较,差异无统计学意义(P>0.05)。年龄>35岁组和年龄≤35岁组EMS患者的抗生殖免疫抗体AOAb、ACL、EMAb阳性率明显高于同龄对照组,差异有统计学意义(P≤0.05)。结论 ENS患者存在抗生殖免疫抗体变化,高孕激素、高泌乳素水平可能与EMS发病有关。
Objective To investigate the relationship between anti-HIV antibody and sex hormones in patients with endometriosis (EMS). Methods A retrospective analysis of 268 patients with EMS (90 patients with EMS in age group 35 and 178 with EMS ≤35 years old) and 200 patients with non-endometriosis Of non-endometriosis patients 72 cases of the same age control group; age ≤ 35 years old group of non-endometriosis 128 cases, the same age control group) clinical data. The levels of serum follicle-stimulating homone (FSH), homone (LH), testosterone (T) and estradiol (E2) progesterone were measured by chemiluminescence immunoassay progesterone, P) and prolactin (PRL) were measured. Anti-ovarian antibodies (AO-Ab), anticardiolipin antibody (ACL) and anti-endometrial antibody (anti-endometrial antibodies, EMAb) levels. Results The levels of P and PRL in EMS patients aged 35 years and younger than 35 years old were significantly higher than those in the same age group, and the difference was statistically significant. The levels of LH in EMS patients aged> 35 years old were also significantly higher than those in the same age group, The difference was also statistically significant (P <0.05). The indexes of other hormones had no significant difference (P> 0.05). The positive rates of AOAb, ACL and EMAb in age group 35 and age 35 were significantly higher than those in the same age group (P <0.05). Conclusion There are anti-reproductive immune antibodies in patients with ENS, high progesterone and high prolactin levels may be related to the pathogenesis of EMS.