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异名 Inhibace, 化学名 ((?))-(1 S,9 S)-9-[[(S)-1-乙氧甲酰-3-苯丙基]氨基]八氢-10-氧-6H-哒嗪[1,2-a][1,2]二氮杂草-1-羧酸一水合物药效分类 ACE抑制剂开发单位 (英)Roche公司上市厂商 (日)罗士制药公司1990年上市药理西拉普利经正常狗、大鼠和几种高血压模型进行药效和药理试验,最长连续给药10周,证实有降血压作用。本药的活性代谢物R031-3113对ACE的抑制效果为依那普利的活性代谢物的2倍左右。本药可以抑制血浆中ACE活性和血管紧张素Ⅰ引起的血压升高,增强缓激肽的降压作用,抑制血管壁去甲肾上腺素引起的血管紧张素Ⅱ
Synonyms Inhibace, chemical name ((?)) - (1 S, 9 S) -9 - [[(S) -1-ethoxycarbonyl-3- phenylpropyl] amino] octahydro- 6-pyridazin [1,2-a] [1,2] diazepine-1-carboxylic acid monohydrate Pharmacodynamic class ACE inhibitor development unit (Roche) Listed manufacturer (day) Pharmacology and pharmacological tests of cilostazol, which was marketed in 1990, were conducted in normal dogs, rats and several hypertensive models for a maximum of 10 consecutive weeks, demonstrating hypotensive effects. The drug’s active metabolite R031-3113 ACE inhibitory effect of enalapril active metabolites about 2 times. The drug can inhibit ACE activity in plasma and angiotensin I caused by elevated blood pressure, increased bradykinin antihypertensive effect, inhibition of vascular wall norepinephrine-induced angiotensin Ⅱ