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ICU病房中,急性肺损伤(Acute lung injury,ALI)是脓毒症常见并发症并有较高发病率和死亡率。研究表明肺血管内皮细胞是脓毒症致ALI的重要靶细胞和效应细胞,肺血管内皮细胞功能紊乱和损伤在脓毒症致ALI发生、发展中有重要作用,本文概述脓毒症致肺血管内皮损伤的相关发病机制。
In the ICU ward, Acute lung injury (ALI) is a common complication of sepsis with high morbidity and mortality. Studies have shown that pulmonary vascular endothelial cells are important target cells and effector cells of ALI induced by sepsis. Pulmonary endothelial cell dysfunction and injury play an important role in the pathogenesis and development of ALI induced by sepsis. Endothelial Injury Related Pathogenesis.