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目的 研究中国妊娠妇女血清瘦素水平与妊娠的关系。方法 采用放射免疫测定 (RIA)方法 ,测定 4 9名妇女妊娠 2 0～ 3 0周时血清瘦素水平 ,并与年龄、体重指数 (BMI)相似的中国女性比较 ,以t检验作统计学分析。同时与妊娠妇女的孕周、体重、BMI、血压等作相关分析。结果 参与研究的 4 9名妊娠妇女 ,与对照组比较 ,瘦素水平差异有显著性 (P均 <0 .0 0 1 )。妊娠妇女血清瘦素水平与其体重、BMI、腹围、舒张压均显著相关(P均 <0 .0 5 ) ;而与妊娠妇女的收缩压关系不大 (P >0 .0 5 )。在观察期间 ,妊娠妇女的瘦素水平随妊娠时间的延长而有增高的趋势 ,但未呈现统计学差异。结论 1、瘦素是与妊娠密切相关的一种激素 ,妊娠期瘦素水平明显高于相近年龄组非妊娠女性 ;2、与非妊娠妇女一样 ,瘦素与妊娠妇女的体重、体重指数相关 ;3、妊娠期瘦素水平与其舒张压相关 ,对妊娠并发症 (如妊娠高血压 )的观察可能有一定的意义
Objective To study the relationship between serum leptin levels and pregnancy in pregnant women in China. Methods Radioimmunoassay (RIA) was used to determine the level of serum leptin in geese from 20 to 30 weeks of gestation, and compared with Chinese women with similar age and body mass index (BMI), t test was used for statistical analysis . Pregnancy, gestational age, weight, BMI, blood pressure and other related analysis. Results There were significant differences in the levels of leptin among 49 pregnant women participating in the study (P <0.01). Serum leptin level in pregnant women was significantly correlated with body weight, BMI, abdominal circumference and diastolic blood pressure (P <0.05), but not with systolic BP in pregnant women (P> 0.05). During the observation period, pregnant women, leptin levels with the extension of pregnancy tend to have an upward trend, but did not show a statistically significant difference. Leptin is a hormone closely related to pregnancy, and the level of leptin during pregnancy is significantly higher than that of non-pregnant women in similar age groups. 2. Leptin is correlated with weight and body mass index of pregnant women as non-pregnant women; 3, pregnancy leptin levels associated with its diastolic blood pressure, pregnancy complications (such as pregnancy-induced hypertension) may have some significance