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为了有效地对付抗药性疟原虫,各国学者都在积极探讨疟原虫的抗药性机理。然而,目前除了对抗乙胺呛喧疟原虫抗药性机理有较清楚的认识外,对抗氯吟。疟原虫抗性产生的机理仍不清楚。本文试图以当前流行的几种疟原虫抗氯峰机理假说为主线,概要介绍疟原虫抗氯吟机理的研究现状。一、与氯喹作用机理相联系的抗药性机理假说当前有关氯喹抗疟作用机理的假说主要有三种,与其相联系的抗药机理假说只有两种。 (一)氯喹-DNA结合假说这一假说的提出最早是基于DNA能改变氯喹吸收光谱,后又证明细菌、哺
In order to effectively deal with drug-resistant Plasmodium, scholars in all countries are actively exploring the mechanism of resistance of Plasmodium. However, at present, there is a clearer understanding of the mechanism of resistance to ethidium cholera protozoa and the fight against chlorophenin. The mechanism by which plasmodium resistance develops remains unclear. This article attempts to take the current prevalence of several types of Plasmodium anti-chloride mechanism hypothesis as the main line, an overview of Plasmodium anti-chlorin mechanism of the status quo. First, the mechanism of resistance associated with chloroquine resistance mechanism Hypothesis There are currently three major hypotheses about the mechanism of chloroquine antimalarial action, and its associated resistance mechanism hypothesis only two. (A) the proposed chloroquine-DNA binding hypothesis was first proposed based on the DNA can change the chloroquine absorption spectra, and later proved that bacteria, feeding