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目的:探讨子痫前期患者子宫螺旋动脉血流动力学、胎盘微血管密度及HSP-70、PAPP-A的变化规律。方法:选取32例子痫前期患者为观察组,同期进行产检的32例健康孕妇为对照组,将两组孕妇的子宫螺旋动脉改变情况及血流动力学指标、胎盘微血管密度、血清HSP-70、PAPP-A水平进行统计及比较。结果:观察组的子宫螺旋动脉无变化者比例高于对照组,PI、RI及S/D水平均高于对照组,随孕周增加呈现降低的趋势,胎盘微血管密度低于对照组,血清HSP-70及PAPP-A均高于对照组,且重度患者变化幅度均大于轻度患者,差异有统计学意义(P均<0.05)。结论:子痫前期患者存在子宫螺旋动脉血流动力学、胎盘微血管密度及HSP-70、PAPP-A的异常,且轻度与重度患者也存在明显的差异。
Objective: To investigate the changes of hemodynamics, placental microvessel density and HSP-70, PAPP-A in patients with preeclampsia. Methods: Thirty-two pregnant women with preeclampsia were selected as observation group and 32 healthy pregnant women as control group during the same period. The changes of uterine spiral artery, hemodynamics, placental microvessel density, serum HSP-70, PAPP-A levels for statistics and comparison. Results: The proportion of uterine spiral artery in the observation group was higher than that of the control group. The levels of PI, RI and S / D in the observation group were higher than those in the control group, and decreased with the increase of gestational age. The density of microvessel in the placenta was lower than that in the control group. -70 and PAPP-A were higher than those in the control group, and the changes in severe patients were greater than those in mild patients, the difference was statistically significant (all P <0.05). Conclusion: There are abnormalities of uterine spiral artery hemodynamics, placental microvessel density, HSP-70 and PAPP-A in patients with preeclampsia, and there are also significant differences between mild and severe patients.