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目的分析非依赖性假性血小板减少患者的临床疾病分布、人群分布以及季节分布的特点,并分析患者对不同抗凝剂的依赖性,以提供相应的临床解决方案。方法收取1 241例非依赖性假性血小板减少患者的标本,分别采用乙二胺四乙酸二钾(EDTA-K2)、枸橼酸钠和肝素进行抗凝,采血后立即进行相关仪器法和手工法(草酸胺)的检测。结果在1 241例患者标本中采用EDTA-K2抗凝时全部聚集,采用枸橼酸钠和肝素进行抗凝时分别有413例和91例凝聚,分别占标本总数的33.3%和7.3%;疾病中以肿瘤及放化疗患者最多,占25.7%,自身免疫性疾病、肝胆系统疾病及呼吸系统疾病分别占18.1%、14.7%和10.4%;季节中以冬季比例最高,达38.1%,夏季最低,仅占13.9%;人群中以41岁~60岁年龄组最多,达46.5%,<10岁组最低,仅占1.3%。结论非依赖性假性血小板减少与患者的疾病类型、年龄及季节有关,更换抗凝剂可以为血小板的临床检测提供帮助。
Objective To analyze the distribution of clinical disease, population distribution and seasonal distribution in patients with non-dependent pseudothrombocytopenia and analyze the dependence of patients on different anticoagulants to provide corresponding clinical solutions. Methods A total of 1,241 patients with non-dependent pseudo-thrombocytopenia were enrolled in this study. EDTA-K2, sodium citrate and heparin were used for anticoagulation respectively. France (oxalate) test. RESULTS: All of the 241 samples collected in the anticoagulation with EDTA-K2 were aggregated with 413 cases and 91 cases aggregated with sodium citrate and heparin, accounting for 33.3% and 7.3% of the total specimens, respectively. The disease Among them, 25.7% were cancer and radiotherapy and chemotherapy, with autoimmune diseases, hepatobiliary diseases and respiratory diseases accounting for 18.1%, 14.7% and 10.4% respectively. In winter, the highest proportion was in winter (38.1%), lowest in summer Accounting for only 13.9% of the total population. Among the population, the age group of 41 to 60 years was the highest (46.5%), and the lowest was in the age group of 10 (1.3%). Conclusions Independent thrombocytopenia is related to the type of disease, age and season in patients. The replacement of anticoagulants can provide clinical support for the clinical detection of platelets.