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目的观察根除幽门螺杆菌(Hp)联合质子泵抑制剂对长期服用阿司匹林患者胃十二指肠损伤的效果。方法选取医院收治的长期服用阿司匹林的心绞痛患者120例为研究对象,随机分为观察组和对照组,每组60例。均采用相应剂量的阿司匹林治疗,在此基础上对照组采用单纯质子泵抑制剂(雷贝拉唑)治疗,观察组采用根除幽门螺杆菌联合质子泵抑制剂治疗(阿莫西林+克拉霉素+雷贝拉唑)。观察比较2组消化道黏膜损伤、Hp阳性率、上消化道症状及消化道黏膜损伤评分。结果观察组消化道黏膜损伤及Hp阳性率均低于对照组(P<0.05);观察组消化道症状评分、消化道黏膜损伤评分值均低于对照组(P<0.05)。结论根除幽门螺杆菌联合质子泵抑制剂能够有效降低长期服用阿司匹林患者胃十二指肠损伤的发生风险与症状严重程度。
Objective To observe the effect of eradication of Helicobacter pylori (Hp) combined with proton pump inhibitor on gastroduodenal injury in long-term aspirin patients. Methods A total of 120 patients with aspirin long-term aspirin admitted to hospital were selected as study subjects and randomly divided into observation group and control group with 60 cases in each group. Were treated with the corresponding dose of aspirin, on the basis of the control group using a simple proton pump inhibitor (rabeprazole) treatment, the observation group using eradication of Helicobacter pylori plus proton pump inhibitor treatment (amoxicillin + clarithromycin + Rabeprazole). The gastrointestinal mucosal injury, Hp positive rate, upper gastrointestinal symptoms and gastrointestinal mucosal injury scores were compared between the two groups. Results The gastrointestinal mucosal lesion and the positive rate of Hp in the observation group were lower than those in the control group (P <0.05). The scores of gastrointestinal symptoms and mucosal damage in the observation group were lower than those in the control group (P <0.05). Conclusion Eradication of Helicobacter pylori combined with proton pump inhibitors can effectively reduce the risk of gastric gastroduodenal injury and the severity of symptoms in long-term aspirin patients.