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严重而相当深度的创伤使组织在修复过程中产生瘢痕。被创伤的组织产生一种基本上是炎症性的肉芽组织。从未受损伤的真皮灶产生的或从创口周围浸润进入的新的成纤维细胞开始为新的结统组织合成必须的产物。它们在早期的肉芽中更多是粘多醣而不是胶原。新的胶原集中于肉芽组织的中心区而在周围先发生消散。伤后2～3日有新的血管发生。周围神经纤维也容易再生。只有上皮源的结构如毛囊及汗腺始终没有再生。血管、新的细胞及细胞外物质的机化和成熟
Severe and considerable depth of the wound tissue in the repair process of scarring. Traumatized tissue produces a substantially inflammatory granulation tissue. New fibroblasts generated from an intact dermal lesion or infiltrated around the wound began to synthesize the necessary products for the new unorganized tissue. They are more mucopolysaccharide than collagen in early granulation. The new collagen concentrated in the central area of granulation tissue around the first occurrence of dissipation. 2 to 3 days after injury with new angiogenesis. Peripheral nerve fibers are also easy to regenerate. Only epithelial structures such as hair follicles and sweat glands never regenerate. Artery and maturation of blood vessels, new cells and extracellular material