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目的:评价口服避孕药对中国女性乳腺癌发病率的影响。方法:计算机及手动检索中国知网,万方,维普,中国生物医学文献数据库,纳入有关口服避孕药对乳腺癌发病影响的研究。在评价纳入研究的方法学质量和提取有效数据后,采用Review Manager5.0进行Meta分析。结果:共纳入19篇病例对照研究,包括例5051患者和6023例对照。Meta分析结果显示:乳腺癌病例组比对照组有着较高的口服避孕药暴露比。结论:口服避孕药可能会增加中国女性乳腺癌的发病风险。
Objective: To evaluate the effect of oral contraceptives on the incidence of breast cancer in Chinese women. Methods: The computer and manual search CNKI, Wanfang, VIP, China Biomedical Literature Database, to study the impact of oral contraceptives on the incidence of breast cancer. After evaluating the methodological quality of the included studies and extracting valid data, Meta-analysis was performed using Review Manager 5.0. RESULTS: A total of 19 case-control studies were included, including 5051 patients and 6023 controls. Meta analysis showed that breast cancer patients had higher oral contraceptive exposure than the control group. Conclusion: Oral contraceptives may increase the risk of breast cancer in Chinese women.