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正在哺乳的妇女乳汁中,分泌性IgA在粘膜免疫中构成重要因素。这些抗体可保护机体抵抗呼吸道、消化道的许多细菌或病毒感染。经母乳传递的分泌性IgA可保护母乳喂养的婴儿,以抵抗各种全身性感染,例如小儿麻痹和霍乱。肠道和乳腺的分泌性IgA反应之间可能有关系,这就指明乳汁中分泌性IgA水平可以反映粘膜对各种疫苗的免疫反应。本文介绍皮下接种死的和经口接种活的小儿麻痹疫苗后,对人乳汁中分泌性IgA滴度的作用。
Secretory IgA is an important factor in mucosal immunity among lactating women’s milk. These antibodies protect the body against many bacterial or viral infections in the respiratory, digestive tract. Breast-delivered secreted IgA protects breast-fed infants against various systemic infections such as poliomyelitis and cholera. Secretory IgA response between the gut and the mammary glands may be related, indicating that secretory IgA levels in milk can reflect mucosal immune responses to various vaccines. This article describes the role of secretory IgA titers in human milk following vaccination of dead and oral live polio vaccines subcutaneously.