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应用放射免疫分析法定测定被不同剂量四氯化碳染毒的小鼠血清结合胆酸的含量,并与血清谷丙转氨酶活性进行比较,探讨了这两项指标的关系。实验结果表明,血清结合胆酸含量在10mg/kg体重四氯化碳染毒组显著高于对照组(p<0.05),而血清谷丙转氨酶活性则在20mg/kg体重四氯化碳染毒组显著高于对照组(p<0.01)。可以认为,就诊断中毒性肝炎而言,检测血清结合胆酸的含量较检测血清谷丙转氨酶活性更为敏感。
A radioimmunoassay was used to determine the level of bile acid bound by different doses of carbon tetrachloride-contaminated mice, and compared with serum alanine aminotransferase activity. The relationship between these two indexes was discussed. The experimental results showed that the concentration of serum bile acids in the carbon tetrachloride exposure group at 10 mg/kg body weight was significantly higher than that in the control group (p<0.05), while the activity of serum alanine aminotransferase was exposed to carbon tetrachloride at 20 mg/kg body weight. The group was significantly higher than the control group (p<0.01). It can be considered that in the diagnosis of toxic hepatitis, the detection of serum bound cholic acid is more sensitive than the detection of serum alanine aminotransferase activity.