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目的探讨心肌缺血后适应对急性心肌梗死(AMI)左心室重构的影响。方法选择急性心肌梗死患者105例,分为缺血后适应组(n=54)及非缺血后适应组(n=51),分别于入院后24小时、1周、1个月及3个月行超声心动图检查,测量左心室舒张末期容积指数(LVEDVI)、左心室收缩末期容积指数(LVESVI)和左心室射血(LVEF)分数。结果缺血后适应组与非缺血后适应组于术后1个月及3个月左心室容积均减小,LVEF分数升高;术后3个月两组左心室舒张期末容积指数(63.5±6.5)ml/m2vs(67.2±6.3)ml/m2,左心室收缩期末容积指数(30.3±3.6)ml/m2vs(34.3±4.1)ml/m2,左心室射血分数(0.53±0.02)%vs(0.50±0.03)%,差异均有统计学意义。结论缺血后适应对AMI具有保护作用,可减轻左心室重构。
Objective To investigate the effect of post-ischemic postconditioning on left ventricular remodeling in acute myocardial infarction (AMI). Methods A total of 105 acute myocardial infarction patients were enrolled in this study. The patients were divided into ischemic postconditioning group (n = 54) and non-ischemic postconditioning group (n = 51) Echocardiography was performed monthly to measure left ventricular end-diastolic volume index (LVEDVI), left ventricular end-systolic volume index (LVESVI) and left ventricular ejection fraction (LVEF). Results The volume of left ventricle decreased and the LVEF increased at 1 month and 3 months after operation in both ischemic group and non-ischemic group. After 3 months, the end-diastolic volume index (63.5 ± 6.5) ml / m2 vs (67.2 ± 6.3) ml / m2, left ventricular end systolic volume index (30.3 ± 3.6) ml / m2 vs (34.3 ± 4.1) ml / m2 and left ventricular ejection fraction (0.53 ± 0.02)% vs (0.50 ± 0.03)%, the differences were statistically significant. Conclusion The ischemic postconditioning has a protective effect on AMI, which can reduce left ventricular remodeling.