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目的：阿罗洛尔的抗高血压疗效和对睡眠呼吸状况的影响。方法：随机、单盲、自身对照法。２０例原发性高血压患者在治疗前后分别接受多导睡眠仪和动态血压等监测。结果：患者服药４周，收缩压从２１．７±２．０ｋＰａ（１６３±１５ｍｍＨｇ）降至１８．９±２．５ｋＰａ（１４２±１９ｍｍＨｇ）（Ｐ＝０．０００，ｎ＝２０），舒张压从１３．５±０．９ｋＰａ（１０１±７ｍｍＨｇ）降至１１．７±０．９ｋＰａ（８８±７ｍｍＨｇ）（Ｐ＝０．０００，ｎ＝２０）。合并睡眠呼吸暂停者治疗后呼吸紊乱指数从２４．６０降至１３．１６（Ｐ＜０．０５，ｎ＝５）。超声心动图结果提示患者心功能状态有显著改善。心率无明显下降，治疗后血浆高密度脂蛋白胆固醇增加，血浆肾素浓度降低。结论：阿罗洛尔有较好的降压疗效，可以减轻睡眠呼吸暂停患者的睡眠呼吸障碍，改善心功能，对代谢无不良影响
Objectives: The antihypertensive effect of arotinolol and its effect on sleep breathing. Methods: Randomized, single-blind, self-control method. Twenty patients with essential hypertension received polysomnography and ambulatory blood pressure monitoring before and after treatment. Results: After 4 weeks of treatment, systolic blood pressure decreased from 21.7 ± 2.0 kPa (163 ± 15 mmHg) to 18.9 ± 2.5 kPa (142 ± 19 mmHg) (P = 0.000, n = 20) From 13.5 ± 0.9 kPa (101 ± 7 mmHg) to 11.7 ± 0.9 kPa (88 ± 7 mmHg) (P = 0.000, n = 20). The respiratory disturbance index in patients with sleep apnea decreased from 24.60 to 13.16 (P <0.05, n = 5). Echocardiographic findings suggest a significant improvement in cardiac function. No significant decrease in heart rate, plasma HDL cholesterol after treatment, plasma renin concentration decreased. Conclusion: Arotinolol has a good antihypertensive efficacy, can reduce sleep apnea in patients with sleep disordered breathing, improve cardiac function, no adverse effects on metabolism