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目的比较来曲唑(LE)与克罗米芬(CC)促排卵作用及妊娠结局。方法选择60例多囊卵巢综合征患者随机分成两组,LE组28例,CC组32例。于月经周期第3～5 d分别服用LE与CC,观察LE与CC对卵泡发育及子宫内膜的影响。结果出现优势卵泡LE组24例,CC组12例,差异有统计学意义(P<0.01)。单卵泡发育LE组23例,CC组4例,差异有统计学意义(P<0.01)。绒毛膜促性腺激素(HCG)注射日子宫内膜平均厚度LE组(8.33±1.94)mm,CC组(5.82±1.53)mm,差异有统计学意义(P<0.01)。结论 LE促排卵效果明显优于CC,且LE组单卵泡发生率明显高于CC组,有效降低了多卵泡发育、卵巢过度刺激综合征和多胎妊娠的发生率。
Objective To compare the ovulation induction and pregnancy outcomes of letrozole (LE) and clomiphene citrate (CC). Methods Sixty patients with PCOS were randomly divided into two groups: 28 in LE group and 32 in CC group. LE and CC were taken on the 3rd to 5th days of the menstrual cycle to observe the effects of LE and CC on follicular development and endometrium. Results The dominant follicle in 24 cases of LE group and CC group of 12 cases, the difference was statistically significant (P <0.01). The single follicles developed LE group in 23 cases, CC group in 4 cases, the difference was statistically significant (P <0.01). The average endometrial thickness of HCG group on day of HCG injection was 8.33 ± 1.94 mm, and CC group was 5.82 ± 1.53 mm, the difference was statistically significant (P <0.01). Conclusions The ovulation-promoting effect of LE is better than that of CC, and the incidence of single follicles in LE group is significantly higher than that in CC group, which effectively reduces the occurrence of multiple follicles, ovarian hyperstimulation syndrome and multiple pregnancy.