论文部分内容阅读
目的:探讨子宫内膜样腺癌组织中真核细胞翻译起始因子4E(eIF4E)的表达情况及意义。方法:应用免疫组织化学技术检测124例子宫内膜样腺癌及20例正常子宫内膜组织中eIF4E的表达情况,同时结合患者的临床病理资料进行分析。结果:子宫内膜样腺癌和正常子宫内膜组织中eIF4E的阳性表达率分别为72.6%和5.0%,差异有统计学意义(P=0.000<0.05)。eIF4E的表达与肿瘤组织分化程度明显相关(P=0.039<0.05),而与FIGO分期无明显相关(P=0.296>0.05)。结论:过度表达的eIF4E可能作为判断子宫内膜恶变及恶性程度的分子标志。
Objective: To investigate the expression and significance of eIF4E in eukaryotic cells in endometrioid adenocarcinoma. Methods: The expression of eIF4E in 124 cases of endometrioid adenocarcinoma and 20 cases of normal endometrium was detected by immunohistochemistry, and analyzed with clinicopathological data. Results: The positive rates of eIF4E in endometrial adenocarcinoma and normal endometrium were 72.6% and 5.0%, respectively, with statistical significance (P = 0.000 <0.05). The expression of eIF4E was significantly correlated with the degree of tumor differentiation (P = 0.039 <0.05), but not with FIGO stage (P = 0.296> 0.05). Conclusion: Overexpression of eIF4E may be used as a molecular marker to determine the degree of malignancy and malignancy of endometrium.