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Irritable bowel syndrome (IBS) is defined by the Rome Ⅲ criteria as symptoms of recurrent abdominal pain or discomfort with the onset of a marked change in bowel habits with no evidence of an inflammatory,anatomic,metabolic,or neoplastic process.As such,many clinicians regard IBS as a central nervous system problem of altered pain perception.Here,we review the recent literature and discuss the evidence that supports an organic based model,which views IBS as a complex,heterogeneous,inter-dependent,and multi-variable inflammatory process along the neuronal-gut axis.We delineate the organic pathophysiology of IBS,demonstrate the role of inflammation in IBS,review the possible differences between adult and pediatric IBS,discuss the merits of a comprehensive treatment model as taught by the Institute of Functional Medicine,and describe the potential for future research for this syndrome.
Irritable bowel syndrome (IBS) is defined by the Rome III criteria as symptoms of recurrent abdominal pain or discomfort with the onset of a marked change in bowel habits with no evidence of an inflammatory, anatomic, metabolic, or neoplastic process. As such, many clinicians regard IBS as a central nervous system problem of altered pain perception. Here, we review the recent literature and discuss the evidence that supports that organic based model, which views IBS as a complex, heterogeneous, inter-dependent, and multi-variable inflammatory process along the neuronal-gut axis. We delineate the organic pathophysiology of IBS, demonstrate the role of inflammation in IBS, review the possible differences between adult and pediatric IBS, discuss the merits of a comprehensive treatment model as taught by the Institute of Functional Medicine , and describe the potential for future research for this syndrome.