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目的评价超分割外照射加立体定向适形放疗治疗局部复发鼻咽癌的临床疗效和毒副作用。方法对2000～2002年收治的14例复发鼻咽癌进行超分割外照射(1.3Gy/次,2次/天,总剂量42～60Gy)加立体定向适形放疗推量(4Gy/次,隔日照射,共10次,总量20Gy)的临床研究。结果总有效率(CR+PR)分别为85.7%(12/14),其中完全消退(CR)64.3%(9/14),部分消退(PR)21.4%(3/14),稳定14.3%(2/14),2年总生存率57.1%(8/14),无瘤生存率42.9%(6/14),靶区肿瘤控制率78.6%(11/14)。结论超分割外照射加立体定向适形放疗治疗局部复发鼻咽癌在临床上是可行及有效的。
Objective To evaluate the clinical effects and toxicity of hyperfractionated external beam plus stereotactic radiotherapy for the treatment of locally recurrent nasopharyngeal carcinoma. Methods 14 cases of recurrent nasopharyngeal carcinoma treated from 2000 to 2002 were treated with stereotactic radiotherapy (4Gy / time, every other day) with hyperfractionated radiotherapy (1.3Gy / time, twice daily, total dose 42-60Gy) , A total of 10 times, a total of 20Gy) clinical research. Results The total effective rate (CR + PR) was 85.7% (12/14), of which 64.3% (9/14) were completely resolved (CR), 21.4% (3/14) partially resolved and 14.3% 2/14). The 2-year overall survival rate was 57.1% (8/14), the tumor-free survival rate was 42.9% (6/14) and the target tumor control rate was 78.6% (11/14). Conclusion Superfractionated external beam plus stereotactic conformal radiotherapy for locally recurrent nasopharyngeal carcinoma is clinically feasible and effective.