环胞霉素A加输新鲜血清治疗免疫复合物型肾小球肾炎

• 作 者: 钟长恩 赵淑华 丁秋兰 刘萍 毕柳
• 出 处: 哈尔滨医科大学学报
• 发表日期: 1996年06期
• 关键词: 胞霉素 实验性血清病 免疫活性 治疗法 肾小球肾炎 循环免疫复合物 动物模型 模型组 治疗作用 兔耳

通过急性实验性血清病（ＡＥＳＳＲ）动物模型，证明了急性实验性血清病血清中ＣＩＣ水平明显高于正常家兔组（Ｐ＜００１），补体溶解免疫活性ＣＭＳＣ水平明显低于正常组（Ｐ＜００１）。环胞霉素Ａ（ＣｓＡ）加输新鲜血清治疗后，治疗组家兔ＣＭＳＣ水平较未治疗组明显升高（Ｐ＜００１），ＣＩＣ水平较未治疗组明显降低（Ｐ＜００１）。说明该疗法治疗ＡＥＳＳＲ家兔免疫复合物引起的肾小球肾炎有一定疗效

The acute experimental serum disease (AESSR) animal model demonstrated that serum CIC level in acute experimental serum was significantly higher than that in normal rabbits (P <001), and that of complement-dissolved immunocompetent CMSCs was significantly lower than that in normal rabbits P <001). After treatment with CsA plus fresh serum, the level of CMSC in the treatment group was significantly higher than that in the untreated group (P <001), and the level of CIC in the treatment group was significantly lower than that of the untreated group (P <001 ). This treatment of AESSR rabbit immune complex induced glomerulonephritis have a certain effect