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目的 :研究华蟾素联合化疗的中西医结合方法治疗晚期消化系统肿瘤 ,观察其近期疗效及毒副反应。方法 :将 51例晚期消化系统肿瘤病人随机分为单纯化疗组及化疗联合华蟾素治疗组 ,单纯化疗组主应用 FAM及 EL FP±HCPT等联合化疗方案 ,联合治疗组化疗方案同前 ,同时应用华蟾素 40 ml～ 50 ml/ d,静滴 ,连用 1 5～ 2 0 d为 1疗程 ,观察近期疗效、毒副反应及生活质量。结果 :华蟾素联合化疗组的有效率为 3 4.6% ,单纯化疗组为 2 4.0 % ,P>0 .0 5,差异无显著性 ;但在改善病人生存质量方面 ,联合治疗组明显优于单纯化疗组 ,P<0 .0 5,差异有显著性。主要副反应为局部血管刺激。提示 :华蟾素联合化疗治疗晚期消化系统肿瘤 ,毒副反应轻 ,疗效好 ,尤其是提高了晚期消化系统肿瘤患者的生存质量。
Objective : To study the treatment of advanced digestive system tumors with combination of Chinese medicine and western medicine with Cinobufacini combined with chemotherapy and observe its short-term curative effect and side effects. METHODS: Fifty-one patients with advanced digestive system cancer were randomly divided into chemotherapy alone group and chemotherapy combined with cinobufagin treatment group. The chemotherapy group combined with FAM and EL FP±HCPT combined chemotherapy was the same. The combined treatment group chemotherapy was the same as before. Application of Huachansu 40 ml ~ 50 ml / d, intravenous infusion, once every 15 to 20 days as a course of treatment, observed the short-term efficacy, toxicity and quality of life. RESULTS: The effective rate of Cinobufagin combined with chemotherapy was 3 4.6%, and that of chemotherapy alone was 24.0%, P>0.05, but the difference was not significant. However, in improving the quality of life of patients, the combined treatment group was significantly better than In the chemotherapy alone group, P<0.05, the difference was significant. The main side effect is local vascular stimulation. Note: Huachansu combined with chemotherapy in the treatment of advanced digestive system tumors, mild side effects, a good effect, especially to improve the quality of life of patients with advanced digestive system cancer.