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本文报告118例高脂血症患者长期眼用谷维素对降低血脂的作用及其安全性的研究结果。用药方法:谷维素颗粒剂(200mg/g); 白色糖衣片(50mg/片),用量以谷维素计,一日3次,每次100mg餐后服。眼药期间禁用影响血脂的药物。服药后定时取血测定血脂(有31例因各种原因未能进行血脂改善情况的评定),并对副作用及服药后血生化、心电图等改变情况进行了评定,观察一年以上。其结果如下: 1.血清总胆固醇(TC):87例眼药前平均值为263+5mg%,服药2个月后的变化率为7.7%,有显著的降低(P<0.001)。其中有78例高胆固醇血症患者,平均TC为271±5mg%,服药2个月的变化率为8.8%,亦见显著降低(P<0.001)。
This article reports 118 patients with hyperlipidemia patients ophthalmic oryzanol on lipid-lowering effect and safety of the results. Medication methods: oryzanol granules (200mg / g); white sugar-coated tablets (50mg / tablet), the amount of oryzanol, three times a day, each 100mg after serving. Eyedrop disabled during the impact of blood lipid drugs. Blood samples were collected for determination of blood lipids after taking the medicine (there were 31 cases failed to evaluate the improvement of blood lipids for various reasons). The side effects and changes of blood biochemistry and electrocardiogram after taking drugs were evaluated and observed for more than one year. The results are as follows: 1. Serum total cholesterol (TC): 87 cases of pre-ophthalmic average of 263 +5 mg%, 2 months after taking the rate of change was 7.7%, a significant reduction (P <0.001). Among them, 78 patients with hypercholesterolemia had an average TC of 271 ± 5 mg% and a rate of change of 8.8% after 2 months of taking the medication, as well as a significant decrease (P <0.001).