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目的:探讨两组三联疗法治疗幽门螺杆菌阳性消化性溃疡的临床效果。方法:选择我中心2010年8月至2011年8月消化性溃疡患者80例,以上患者均经胃镜检查证实,均为幽门螺杆菌感染阳性患者。上述患者随机分为观察组和对照组。观察组患者给予硫糖铝、洛赛克和阿莫西林三联疗法:其中硫糖铝1.0g口服,每天3次;洛赛克20mg口服,每天2次;阿莫西林1.0g口服,每天2次。对照组患者给予硫糖铝、甲硝唑和克拉霉素三联疗法:硫糖铝1.0g口服,每天3次;甲硝唑0.5g口服,每天2次;克拉霉素0.5g口服,每天2次。两组患者均治疗2周。结果:观察组溃疡愈合率与对照组比较差异有统计学意义(P<0.05);观察组幽门螺杆菌根除率与对照组比较,差异有统计学意义(P<0.05).结论:硫糖铝、洛赛克和阿莫西林三联疗法治疗幽门螺杆菌阳性消化性溃疡疗效显著,优于硫糖铝、甲硝唑和克拉霉素三联疗法。
Objective: To investigate the clinical effect of two groups of triple therapy on Helicobacter pylori positive peptic ulcer. Methods: 80 patients with peptic ulcer were selected from our center from August 2010 to August 2011. All of the above patients were confirmed by gastroscopy, all of whom were H. pylori-positive patients. The above patients were randomly divided into observation group and control group. Patients in the observation group were given sucralfate, Losec and amoxicillin triple therapy: 1.0g sucralfate orally, 3 times daily; Losec 20mg orally twice daily; amoxicillin 1.0g orally twice daily . Control patients were given sucralfate, metronidazole and clarithromycin triple therapy: sucralfate 1.0g orally 3 times a day; metronidazole 0.5g orally twice daily; clarithromycin 0.5g orally twice daily . Two groups of patients were treated for 2 weeks. Results: The healing rate of ulcer in the observation group was significantly lower than that in the control group (P <0.05), and the difference was significant between the observation group and the control group (P0.05) .Conclusion: The sucralfate , Losec and amoxicillin triple therapy for the treatment of Helicobacter pylori positive peptic ulcer significant effect, better than sucralfate, metronidazole and clarithromycin triple therapy.