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目的探讨埃索美拉唑三联治疗十二指球部溃疡的临床疗效。方法选取2013年7月至2014年7月到我院进行救治的86例十二指球部溃疡患者作为研究对象。采取随机分配原则将患者分为3组。埃索美拉唑组(29例),奥美拉唑组(29例),法莫替丁组(28例)。先采用三联法给予3组患者治疗。连续治疗一周后,单独使用埃索美拉唑或奥美拉唑或法莫替丁(各20mg)治疗1周,每天1次,治疗两周后,观察3组患者的病情改善情况,并对全部患者的溃疡愈合情况、HP进行标准检测。并针对3组的结果进行统计学计算。结果埃索美拉唑组的病情改善情况明显优于其他两组,埃索美拉唑组溃疡治愈率98.1%、奥美拉唑组溃疡治愈率92.6%、法莫替丁组溃疡治愈率89.4%。HP根除率分别为96.1%、91.2%、85.6%。差异有统计学意义(P<0.05)。结论埃索美拉唑治疗十二指球部溃疡效果更加明显。
Objective To investigate the clinical efficacy of esomeprazole triple therapy in the treatment of duodenal ulcer. Methods Totally 86 patients with duodenal ulcer who were treated in our hospital from July 2013 to July 2014 were enrolled in this study. The patients were divided into 3 groups according to the principle of random distribution. Esomeprazole group (29 cases), omeprazole group (29 cases) and famotidine group (28 cases). The first triple therapy to give three groups of patients treatment. After a week of continuous treatment, esomeprazole alone or omeprazole or famotidine (each 20mg) for 1 week, once a day, after two weeks of treatment, to observe the improvement of the three groups of patients, and All patients with ulcer healing, HP for standard testing. The results of the three groups were statistically calculated. Results The esoproxazolam group was significantly better than the other two groups. The ulcer cure rate in esomeprazole group was 98.1%, the ulcer cure rate in omeprazole group was 92.6%, the cure rate in famotidine group was 89.4 %. HP eradication rates were 96.1%, 91.2% and 85.6% respectively. The difference was statistically significant (P <0.05). Conclusion Esomeprazole treatment of duodenal ulcer more obvious effect.