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目的:研究内科抗生素的临床便理应用与耐药情况。方法:选择2013年2月至2014年12月我院内科开出的1000张抗生素应用处方作为研究对象,研究抗生素临床合理应用情况,随机选择其中500例抗生素应用患者做药敏试验和细菌培养,研究抗生素应用耐药情况。结果:抗生素临床应用2种抗生素联用情况占42%,明显高于单纯使用1种抗生素或联用3种抗生素比例,头孢类抗生素应用比例明显比其他抗生素应用比较高。1000例处方中有50例出现不合理用药情况,原因多为药物配伍、给药方式或溶媒不对等不合理。结论:内科抗生素的临床应用需要有严格的原则,内科临床对抗生素用药还存在很多不合理情况,抗生素应用同时,还要注意患者耐药性,为患者合理选择用药,取得理想的治疗效果。
OBJECTIVE: To study the clinical application and drug resistance of medical antibiotics. Methods: From January 2013 to December 2014, 1000 prescriptions of antibiotics prescribed by Department of Internal Medicine in our hospital were selected as research objects to study the rational clinical application of antibiotics. Randomly selected among them, 500 cases of antibiotics were used for drug sensitivity test and bacterial culture, Study antibiotic drug resistance. Results: In the clinical application of antibiotics, the combination of two kinds of antibiotics accounted for 42%, which was obviously higher than that of one antibiotic alone or in combination with three antibiotics. The proportion of cephalosporin antibiotics was obviously higher than that of other antibiotics. 50 cases out of 1000 cases of irrational drug use, mostly due to drug compatibility, mode of administration or solvent is not reasonable and unreasonable. Conclusion: The clinical application of medical antibiotics need to have strict principles. There are still many unreasonable cases in medical clinical antibiotics. In the meantime, we should also pay attention to the drug resistance of patients for rational use of antibiotics and achieve the desired therapeutic effect.