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阻塞性睡眠呼吸暂停(OSA)期间心率(HR)减慢对其诊断有一定意义,但其机制未明。最近动物实验研究证实,刺激上气道感受器可兴奋延髓呼吸中枢吸气后神经元,引起HR和呼吸节律的改变。由于OSA可引起上气道萎陷,从而刺激上气道感受器,为此研究了OSA期间和借Mueller法(MM)形成的胸内负压期间HR和呼吸节律的相互关系。对象和方法 OSA患者15例,年龄53±8岁,呼吸暂停指数(AHI)为43.4±27.2/h(诊断标准为AHI>10/h)。另以15名健康人作对照。受试者用多导睡眠仪连续监测两夜,记录非快速眼动相睡眠时HR和总呼吸周期时间(TOT)的变化。计算呼吸暂
Heart rate (HR) slowing during obstructive sleep apnea (OSA) is of diagnostic significance, but its mechanism is unknown. Recent animal experiments confirmed that stimulation of the airway receptors can excite medulla oblongata inspiratory neurons, causing changes in HR and respiratory rhythm. Because OSA can cause upper airway collapse and thereby stimulate upper airway receptors, we investigated the relationship between HR and respiratory rhythm during OSA and intrathoracic negative pressure developed by the Mueller method (MM). Subjects and Methods Fifteen OSA patients, aged 53 ± 8 years, had an apnea index (AHI) of 43.4 ± 27.2 / h (diagnostic criteria AHI> 10 / h). Another 15 healthy people as a control. Subjects were continuously monitored for two nights with a polysomnograph and recorded HR and total respiratory cycle time (TOT) changes during non-REM sleep. Calculate breathing temporarily