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为观察女性内分泌调节轴即下丘脑-脑垂体-卵巢轴功能与妊娠后性激素水平间的相互作用及对妊娠高凝状态的影响．采用放免法测定了妊娠各期及脐静脉血睾酮（T）、雌二醇地（E2）、促卵泡生成素（FSH）、促黄体生成素（LH）、血检索B2（TXB2）、6-酮-前列环素（6－K－PGF1∞）。结果发现：妊娠使E2持续增高，刺激下丘脑GURH释放脉冲，导致雌激素强烈正反馈．促进了FSH、LH释做。高水平雌激素促发血小板花生四烯酸代谢紊乱，诱发妊娠期高凝状态。由于妊娠期高水平雌激素影响．使胎儿脐血中E2、FSH、LH亦处高水平。结果表明；下丘脑-脑垂体-卵巢轴在妊娠后变化使雌激素代谢产生一系列增高，并引起脐血相应的变化，是诱发妊娠期高凝状态及其症病的原因。脐血性激素水平及花生四烯酸含量异常．可能对新生儿血栓和出血性疾病诊断有意义。
To observe the female endocrine axis, hypothalamic-pituitary-ovarian axis function and the level of sex hormone levels after pregnancy and pregnancy hypercoagulable state. The serum levels of testosterone (T), estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), TXB2, 6- Keto-prostacyclin (6-K-PGF1 ∞). The results showed that: E2 continued to increase pregnancy, stimulation of hypothalamic GURH release pulse, resulting in strong positive feedback of estrogen. Promote the FSH, LH release to do. High levels of estrogen to promote platelet arachidonic acid metabolism disorders, induced hypercoagulability during pregnancy. Due to high levels of estrogen during pregnancy. The fetal cord blood E2, FSH, LH is also at a high level. The results showed that the changes of hypothalamus-pituitary-ovarian axis after pregnancy caused a series of estrogen metabolism increase, and caused the corresponding changes in cord blood, which is the reason of inducing hypercoagulable state and its disease in pregnancy. Umbilical cord blood hormone levels and arachidonic acid content abnormalities. It may be useful in the diagnosis of neonatal thrombosis and hemorrhagic disease.