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目的探讨汕头地区男性不育人群中原因不明的无精子症和严重少精子症及与Y染色体无精子因子(AZF)微缺失的关系。方法以PCR体外扩增和电泳检测技术检测汕头地区男性不育人群的Y染色体AZF微缺失情况。结果患者组179例中检出25例Y染色体AZF微缺失,对照组(20例)Y染色体AZF15个位点无缺失。结论 Y染色体AZF微缺失是造成男性无精子症或严重少精子症的病因之一,对本地区男性不育人群进行Y染色体AZF微缺失检测具有重要的理论和实践意义。
Objective To investigate the association between unexplained azoospermia and severe oligozoospermia and microdeletion of Y-chromosome azoospermia (AZF) in male infertile population in Shantou. Methods The Y chromosome AZF microdeletion in male infertile population in Shantou was detected by PCR in vitro amplification and electrophoresis. Results A total of 25 Y chromosome AZF microdeletions were detected in 179 patients in the patient group and 15 AZF loci in the control group (20 patients). Conclusion Y chromosome AZF microdeletion is one of the causes of male azoospermia or severe oligospermia. It is of great theoretical and practical significance to detect the Y chromosome AZF microdeletions in male infertile population in this area.