论文部分内容阅读
研究通过体外循环机加温并加用大剂量化疗药对晚期肺癌的治疗作用。方法 :肺动脉插入灌注管 ,上、下肺静脉插入引流管 ,建立单侧肺隔离进行体外循环 ,将肺循环温度升至 (42± 1)℃持续 45～ 6 0min。结果 :无手术死亡。CR 3例 ,PR 11例 ,NC 1例。 1、2年生存率为 86 7%、6 6 7%。手术 2周后 ,T细胞及NK细胞活性明显提高。结论 :41～ 43℃温度灌注对正常肺组织无明显损害 ,可应用大剂量化疗药进行单侧肺灌注 ;明显改善临床症状及伴发症 ;增强机体免疫功能。
To study the effect of heating by extracorporeal circulation machine and adding high-dose chemotherapy drugs to advanced lung cancer. Methods: Pulmonary artery was inserted into the perfusion tube, the upper and lower pulmonary veins were inserted into the drainage tube, and unilateral lung isolation was established for extracorporeal circulation. The temperature of the pulmonary circulation was increased to (42± 1)°C for 45-60 min. Result : No operative death. There were 3 cases of CR, 11 cases of PR, and 1 case of NC. The 1-year and 2-year survival rates were 86.7% and 66.7%. After 2 weeks of surgery, the activity of T cells and NK cells increased significantly. Conclusion: The temperature of 41～43°C perfusion has no obvious damage to the normal lung tissue. It can be used for unilateral lung perfusion with high-dose chemotherapeutic drugs; it can obviously improve the clinical symptoms and concomitant diseases and enhance the immune function.