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目的探究腰大池置管持续引流联合鞘内注射给药治疗结核性脑膜炎的临床效果。方法 60例结核性脑膜炎患者,随机分为实验组与参照组,各30例。参照组予以常规治疗,实验组在此基础上予以腰大池置管持续引流联合鞘内注射给药治疗,比较两组患者的治疗总有效率、相关脑脊液指标以及住院时间。结果实验组患者中显效22例,有效7例,无效1例,治疗总有效率为96.67%;参照组患者中显效12例,有效12例,无效6例,治疗总有效率为80.00%;两组比较差异具有统计学意义(P<0.05)。实验组患者颅内压、细胞计数、脑脊液蛋白质低于参照组,脑脊液氯化物、糖含量高于参照组,比较差异具有统计学意义(P<0.05)。实验组患者的住院时间为(15.4±2.1)d,参照组患者住院时间为(21.7±2.4)d,实验组患者的住院时间显著短于参照组,比较差异具有统计学意义(P<0.05)。结论腰大池置管持续引流联合鞘内注射给药治疗结核性脑膜炎效果显著,可有效改善患者症状及体征,提高患者的临床治疗效果,缩短住院时间,值得推广。
Objective To investigate the clinical effect of continuous drainage of lumbar cistern with intrathecal injection for the treatment of tuberculous meningitis. Methods Sixty patients with tuberculous meningitis were randomly divided into experimental group and reference group, with 30 cases in each group. The reference group was given routine treatment. On the basis of this, the experimental group was treated with continuous drainage of the lumbar cistern and intrathecal injection, and the total effective rate, related cerebrospinal fluid index and hospital stay of the two groups were compared. Results In the experimental group, 22 cases were markedly effective, 7 cases were effective and 1 case was ineffective. The total effective rate was 96.67%. In the reference group, 12 cases were markedly effective, 12 cases were effective and 6 cases were ineffective. The total effective rate was 80.00% The difference was statistically significant (P <0.05). The intracranial pressure, cell count, CSF protein in the experimental group were lower than those in the reference group, and the contents of chloride and carbohydrate in cerebrospinal fluid were higher than those in the reference group (P <0.05). The hospitalization time was 15.4 ± 2.1 days in experimental group and 21.7 ± 2.4 days in reference group. The hospitalization time in experimental group was significantly shorter than that in reference group (P <0.05) . Conclusion Continuous drainage of the lumbar cistern with intrathecal injection of intrathecal injection is effective in treating tuberculous meningitis, which can effectively improve the symptoms and signs of patients, improve the clinical effect and shorten the length of hospital stay, which is worthy of popularization.