论文部分内容阅读
为评估胰岛素在大于孕龄儿形成中的作用，采用放射免疫分析法（ＲＩＡ）测定大于孕龄儿（ＬＧＡ）３０例、小于孕龄儿（ＳＧＡ）３６例及正常胎儿（ＡＧＡ）３３例的脐血清胰岛素的浓度。结果显示，ＬＧＡ组、ＡＧＡ组及ＳＧＡ组脐血清胰岛素水平分别为（２８．１４±２０．７３）ｍＩＵ／Ｌ、（１１．８９±９．６７）ｍＩＵ／Ｌ、（８．７７±６．８８）ｍＩＵ／Ｌ。ＬＧＡ组脐血清胰岛素水平较ＳＧＡ组显著升高（ｔ＝３．７８，Ｐ＜０．０１），小于孕龄儿组脐血清胰岛素水平较正常组无统计学意义（ｔ＝１．３７，Ｐ＞０．０５）。提示ＬＧＡ存在高胰岛素状态，且脐血清胰岛素水平可能对ＬＧＡ有重要的预测作用。胰岛素对ＬＧＡ的形成有重要作用，而与ＳＧＡ形成无关。
To assess the role of insulin in the development of children older than gestational age, radioimmunoassay (RIA) was used in 30 cases of LGA, 36 cases of gestational age (SGA) and 33 cases of normal fetus (AGA) Umbilical serum insulin concentration. The results showed that the levels of umbilical serum insulin in LGA group, AGA group and SGA group were (28.14 ± 20.73) mIU / L, (11.89 ± 9.67) mIU / L and (8.77 ± 6) 88) mIU / L. Umbilical serum insulin level in LGA group was significantly higher than that in SGA group (t = 3.78, P <0.01), while serum umbilical serum insulin level in LGA group was significantly lower than that in SGA group (t = 1.37, P > 0.05). Suggesting LGA hyperinsulinemia, and umbilical serum insulin levels may have an important role in predicting LGA. Insulin plays an important role in the formation of LGA, but not with SGA formation.