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目的:探讨红核妇洁洗液治疗妊娠期外阴阴道假丝酵母菌病(VVC)的安全性及有效性。方法:对154例妊娠期VVC患者采用简单抽样法随机分为2组各77例,治疗组给予咪康唑栓联合红核妇洁洗液进行治疗,对照组则单纯予以咪康唑栓阴道给药治疗,观察对比2组患者用药后临床疗效、VVC症状评分、不良反应及复发情况。结果:治疗后痊愈率、总有效率治疗组分别为74.0%、98.7%,对照组分别为41.6%、71.4%,2组比较,差异均有显著性意义(P<0.05)。治疗后2组VVC症状评分均较治疗前明显降低(P<0.05),治疗组降低较对照组更显著(P<0.05)。随访6月,不良反应发生率治疗组为3.9%,对照组为6.5%,2组比较,差异无显著性意义(P>0.05)。治疗后治疗组复发5例(6.5%),对照组复发13例(16.9%),2组比较,差异有显著性意义(P<0.05)。结论:对妊娠期VVC患者予以常规阴道给药联合红核妇洁洗液治疗,疗效确切,可有效改善各相关症状,对胎儿影响小,值得临床推广。
Objective: To investigate the safety and efficacy of “Redhead Cleansing Lotion” in the treatment of vulvovaginal candidiasis (VVC) during pregnancy. Methods: One hundred and seventy-four cases of VVC during pregnancy were randomly divided into two groups (n = 77). The patients in the treatment group were treated with miconazole suppository combined with KKR. The control group was treated with miconazole suppository vaginal. The clinical efficacy, VVC symptom score, adverse reactions and relapse were compared between two groups after treatment. Results: After treatment, the cure rate and total effective rate were 74.0% and 98.7% in the treatment group and 41.6% and 71.4% in the control group respectively. There was significant difference between the two groups (P <0.05). After treatment, the scores of VVC in both groups were significantly lower than those before treatment (P <0.05), and those in the treatment group were significantly lower than those in the control group (P <0.05). Follow-up in June, the incidence of adverse reactions in the treatment group was 3.9%, control group was 6.5%, two groups, the difference was not statistically significant (P> 0.05). After treatment, 5 cases (6.5%) relapsed in the treatment group and 13 cases (16.9%) in the control group. There was significant difference between the two groups (P <0.05). Conclusion: The routine vaginal administration of VVC in pregnant women during pregnancy is effective in treating all the relevant symptoms, which has little effect on the fetus and is worthy of clinical promotion.