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目的 对海洋生物提取物海洋星虫胶囊进行安全毒性评价。方法 通过急性毒性试验、30d喂养试验以及致突变试验对海洋星虫胶囊进行毒性评价。结果 (1 )急性毒性试验显示海洋星虫胶囊的LD50 大于 1 0 .0g·kg-1 ;(2 )Ames试验、骨髓微核试验、精子畸形试验均为阴性结果 ;(3) 30d给药结果显示海洋星虫胶囊未见毒性反应 ,未见体内蓄积中毒。结论 海洋星虫胶囊在所试条件下 ,未发现致突变作用 ,未发现遗传毒性 ,无明显体内蓄积中毒
Objective To evaluate the safety and toxicity of marine extracts of marine starworm capsules. Methods Toxicity evaluation of marine starworm capsules was conducted through acute toxicity test, 30 d feeding test and mutagenicity test. Results (1) Acute toxicity test showed that the LD50 of marine starworm capsules was greater than 10.0 g·kg-1; (2) Ames test, bone marrow micronucleus test, and sperm abnormality test were all negative results; (3) 30 d drug administration results No toxic reaction was observed in the marine star insect capsules, and there was no accumulation of poison in the body. Conclusion No evidence of mutagenicity was found in marine starworm capsules under the tested conditions, no genotoxicity was found, no obvious accumulation of poisoning in vivo.