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检测３６例柯萨奇Ｂ组病毒性脑炎患儿血清免疫球蛋白及ＩｇＧ亚类浓度，Ｔ细胞亚群，ＰＨＡ（植物血凝素）皮肤试验等变化。结果表明患儿组ＩｇＭ值明显高于对照组；ＩｇＧ亚类缺陷检出率为３６１１％，以ＩｇＧ１缺陷为主；外周血ＣＤ３、ＣＤ４细胞百分率降低，ＣＤ８细胞百分率增高，而致ＣＤ４／ＣＤ８比值降低；ＰＨＡ试验阳性率为３８８９％。提示柯萨奇Ｂ组病毒性脑炎患儿存在有ＩｇＧ亚类失衡及Ｔ细胞功能紊乱。为阐明病脑的发病机理及使用免疫制剂治疗提供理论依据。
36 cases of Coxsackie B virus encephalitis in children serum immunoglobulin and IgG subclasses concentration, T cell subsets, PHA (phytohemagglutinin) skin test changes. The results showed that the IgM value in children was significantly higher than that in control group. The detection rate of IgG subclass defect was 3611%, which was mainly IgG1 deficiency. The percentage of CD3 and CD4 cells in peripheral blood decreased and the percentage of CD8 cells increased. CD8 ratio decreased; PHA test positive rate was 3889%. Tip Coxsackie B virus encephalitis in children with IgG subclass imbalance and T cell dysfunction. To clarify the pathogenesis of the disease brain and the use of immunotherapy to provide a theoretical basis.