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应用偶氮基质显色法测定恶性梗阻性黄疸患者血浆内毒素，发现梗阻性黄疸患者血浆内毒素含量明显高于正常人，构成内毒素血症。此类患者术前口服乳果糖，结果内毒素含量明显低于对照组，说明口服乳果糖可预防和治疗内毒素血症。
Azo-substrate chromogenic assay was used to detect plasma endotoxin in patients with obstructive jaundice. The plasma endotoxin level in patients with obstructive jaundice was significantly higher than that in normal subjects, which constituted endotoxemia. The preoperative oral administration of lactulose in these patients resulted in a significantly lower endotoxin content than in the control group, indicating that oral lactulose can prevent and treat endotoxemia.