论文部分内容阅读
目的:探讨胃癌组织中白介素12(IL12)与白介素18(IL18)的表达,及其与胃癌临床病理特征、血管生成及预后的关系。方法:选取50例胃癌标本,通过免疫组化检测IL12与IL18在胃癌组织中的表达,显微图像分析系统测定微血管密度。结果:IL12与IL18在胃癌中的阳性表达率分别为44%(22/50)和26%(13/50),IL12与病理分化(P=0.029)、浸润深度(P=0.002)、淋巴结转移(P=0.002)、远处转移(P=0.003)和TNM分期(P=0.005)相关,IL18与远处转移密切相关(P=0.001);多因素生存分析显示IL12、MVD和T分期是胃癌的独立预后因素。结论:IL12和IL18阳性表达与肿瘤进展和转移有关,IL12是提示胃癌患者预后不良的独立因素。
Objective: To investigate the expression of interleukin 12 (IL12) and interleukin 18 (IL18) in gastric cancer and its relationship with clinicopathological characteristics, angiogenesis and prognosis of gastric cancer. Methods: Fifty gastric cancer specimens were selected and the expression of IL12 and IL18 in gastric cancer tissues was detected by immunohistochemistry. The microvessel density was measured by microscopic image analysis system. Results: The positive rates of IL12 and IL18 in gastric cancer were 44% (22/50) and 26% (13/50), respectively. The positive rates of IL12 and pathological differentiation (P = 0.029), depth of invasion (P = 0.002), distant metastasis (P = 0.003) and TNM stage (P = 0.005), IL18 was closely related to distant metastasis (P = 0.001). Multivariate survival analysis showed that IL12, MVD and T staging were gastric cancer Independent prognostic factors. Conclusion: The positive expression of IL12 and IL18 is related to tumor progression and metastasis. IL12 is an independent prognostic factor for gastric cancer.