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目的:分析西咪替丁与临床常用维生素及高危药品配伍稳定性。方法:按照临床上常规的用药配制相应药物溶液的浓度以及西咪替丁与各种药物的配伍液,利用紫外分光光度法来测量西咪替丁和维生素C、维生素B6、异丙嗪、酚妥拉明的含量。外部环境是在25℃左右,在0、2、4、6h这几个时间段内取样来观察配伍液的外观、p H值以及含量的变化等。结果:经过观察,在配伍液静置了6个小时后,这些配伍液都没有发生明显的颜色变化,且也没有产生气泡和沉淀;配伍液在静置的6小时内,p H值没有变化,各组药品的含量也没有发生明显的变化。结论:说明西咪替丁与临床常用维生素及高危药品在室温下放置6小时,配伍液还是相对比较稳定的,不存在物理性配伍禁忌。
Objective: To analyze the compatibility of cimetidine with clinically used vitamins and high-risk drugs. Methods: According to the clinical routine preparation of the corresponding drug solution concentration and cimetidine and various drug compatibility solution, the use of UV spectrophotometry to measure cimetidine and vitamin C, vitamin B6, promethazine, phenol Toramin content. The external environment is about 25 ℃, 0,2,4,6 h in these time periods to observe the appearance of the compatibility of the sample, p H value and content changes. Results: It was observed that no significant color change occurred in these compatibility solutions after 6 hours of compatibility with the compatibility solution, and no air bubbles and precipitation were observed. There was no change in p H value within 6 hours of standing solution , The content of each group of drugs did not change significantly. Conclusion: It shows that the cimetidine and clinical commonly used vitamins and high-risk drugs at room temperature for 6 hours, the compatibility of the liquid is relatively stable, there is no physical incompatibility.